2925457-27-6

2925457-27-6 structure

Name: BChE/HDAC6-IN-1
Chemical Name: BChE/HDAC6-IN-1
CAS Number: 2925457-27-6
Molecular Formula: C₃₄H₄₃N₅O₅
Molecular Weight: 601.74
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2024-09-23 18:59:33
Modify Date: 2024-09-23 18:59:33
BChE/HDAC6-IN-1 is a potent and selective dual BChE/HDAC6 inhibitor with IC50 values of 4 and 8.9 nM, respectively. BChE/HDAC6-IN-1 ameliorates the cognitive impairment in an Aβ1–42-induced mouse model and has the potental for AD research[1].

Name	BChE/HDAC6-IN-1

Description	BChE/HDAC6-IN-1 is a potent and selective dual BChE/HDAC6 inhibitor with IC50 values of 4 and 8.9 nM, respectively. BChE/HDAC6-IN-1 ameliorates the cognitive impairment in an Aβ1–42-induced mouse model and has the potental for AD research[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Lei Wang, ET AL. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2023 Sep 6;14(17):3226-3248.

Molecular Formula	C₃₄H₄₃N₅O₅
Molecular Weight	601.74