CB2R/FAAH modulator-3

Names

[ Name ]:
CB2R/FAAH modulator-3

Biological Activity

[Description]:

CB2R/FAAH modulator-3 (compound 27) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-3 are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 3.4 μM. CB2R/FAAH modulator-3 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> FAAH

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

CB1:67.6 nM (Ki)

CB2:20.1 nM (Ki)

[In Vitro]

CB2R/FAAH modulator-3 (compound 27)(10 μM) 在未刺激的单核细胞和巨噬细胞中，可以降低促炎细胞因子 TNFα、IFN-γ、IL-1β 和 IL6 的产生[1]。

[References]

[1]. Francesca Intranuovo, et al. Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₁NO₂

[ Molecular Weight ]:
341.49

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.