CB2R/FAAH modulator-2

Names

[ CAS No. ]:
2876918-68-0

[ Name ]:
CB2R/FAAH modulator-2

Biological Activity

[Description]:

CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> FAAH
Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

CB1:152.9 nM (Ki)

CB2:10.8 nM (Ki)


[In Vitro]

CB2R/FAAH modulator-2 (compound 26)(10 μM) 在未刺激的单核细胞和巨噬细胞中，可以降低促炎细胞因子 TNFα、IFN-γ、IL-1β 和 IL6 的产生[1]。

[References]

[1]. Francesca Intranuovo, et al. Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H33NO2

[ Molecular Weight ]:
367.52

Related Compounds