DHFR-IN-1
Names
[ CAS No. ]:
2757991-65-2
[ Name ]:
DHFR-IN-1
Biological Activity
[Description]:
DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249[1].
[Related Catalog]:
[Target]
IC50: 40.71 ± 1.86 nM (DHFR)[1]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C22H22N6O4S2
[ Molecular Weight ]:
498.58