SPT-IN-1

Names

[ CAS No. ]:
1933533-18-6

[ Name ]:
SPT-IN-1

[Synonym ]:
MFCD31579859
[4-(6-Heptanoylimidazo[1,2-a]pyridin-8-yl)phenyl]acetic acid
Benzeneacetic acid, 4-[6-(1-oxoheptyl)imidazo[1,2-a]pyridin-8-yl]-
4-[6-(1-Oxoheptyl)imidazo[1,2-a]pyridin-8-yl]benzeneacetic acid

Biological Activity

[Description]:

SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

IC50: 5.19 nM (hSPT1)[1]


[In Vitro]

SPT-IN-1 (compound 1) exhibits a dose-dependent inhibition of C14-serine incorporation into ceramide in MCF-7 cells, with EC50 of 0.98 μM[1].

[In Vivo]

SPT-IN-1 (compound 1) (Sprague Dawley rats, 0-60 mg/kg, Orally, twice daily for 7 days) dose-dependently reduces plasma ceramides, reduces triglycerides and raises HDL in cholesterol/cholic acid fed rats[1].

[References]

[1]. Genin MJ, et al. Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase. J Med Chem. 2016;59(12):5904-5910.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C22H24N2O3

[ Molecular Weight ]:
364.44

[ Exact Mass ]:
364.178680

[ LogP ]:
3.78

[ Index of Refraction ]:
1.603

Related Compounds