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Levobupivacaine hydrochloride

Names

[ CAS No. ]:
27262-48-2

[ Name ]:
Levobupivacaine hydrochloride

[Synonym ]:
levobupivacaine monohydrochloride
Levobupivacainehydrochloride
(S)-(-)-BUPIVACAINE HCL
Levobupivacaine Hydrochloride
L-BUPIVACAINE HYDROCHLORIDE
L-(-)-Bupivacaine
(S)-Bupivacaine hydrochloride
(RS)-bupivacaine hydrochloride
BUPIVACAINE HCL
Levobupivacaine HCl
bupivacaine.hydrochloride
MFCD01704265
(-)-Bupivacaine hydrochloride
Chirocaine
(2S)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride (1:1)
2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, (2S)-, hydrochloride (1:1)
1-butyl-piperidine-2-carboxylic acid-(2,6-dimethyl-anilide),hydrochloride
LEVAMISOLHCLSALT
(2S)-1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride (1:1)
(S)-(-)-Bupivacaine hydrochloride
(S)-Bupivacaine
(-)-Bupicaine Hydrochloride
bupicainehydrochloride(-)
Levobupivacaine (hydrochloride)

Biological Activity

[Description]:

Levobupivacaine Hcl is a local anaesthetic compound belonging to the amino amide group; long-acting local anesthetic.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
Research Areas >> Others

[References]

[1]. Burlacu CL, et al. Update on local anesthetics: focus on levobupivacaine. Ther Clin Risk Manag. 2008 Apr;4(2):381-92.

[2]. Gulec D, et al. Intrathecal bupivacaine or levobupivacaine: which should be used for elderly patients? J Int Med Res. 2014 Apr;42(2):376-85.


[Related Small Molecules]

U73122 | D609 | Darapladib | Quinacrine (dihydrochloride) | FIPI | Melittin | Varespladib | CAY10650 | AA26-9 | ML348 | Tanshinone I | Methyl Arachidonyl Fluorophosphonate | ML 349 | 1-Monolinolein | Lp-PLA2 -IN-1

Chemical & Physical Properties

[ Boiling Point ]:
423.4ºC at 760 mmHg

[ Melting Point ]:
254 °C (dec.)(lit.)

[ Molecular Formula ]:
C18H29ClN2O

[ Molecular Weight ]:
324.889

[ Flash Point ]:
209.9ºC

[ Exact Mass ]:
324.196838

[ PSA ]:
23.55000

[ LogP ]:
4.74080

[ Vapour Pressure ]:
2.24E-07mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TK6120000
CHEMICAL NAME :
2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride, (-)-
CAS REGISTRY NUMBER :
27262-48-2
LAST UPDATED :
198209
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C18-H28-N2-O.Cl-H
MOLECULAR WEIGHT :
324.94
WISWESSER LINE NOTATION :
T6NTJ A4 BVMR B1 F1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
63 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
207 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
T+: Very toxic;Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S36/37/39-S45-S36/37-S53

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
TK6125000

[ HS Code ]:
2942000000

Customs

[ HS Code ]: 2942000000

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