D609

Names

[ Name ]:
D609

[Synonym ]:
Tricyclodecan-9-yl xanthate potassium salt
D609
Carbonodithioic acid, O-(octahydro-4,7-methano-1H-inden-5-yl) ester, potassium salt (1:1)
TRICYCLODECAN-9-YL XANTHOGENATE K
potassium O-(octahydro-1H-4,7-methanoinden-5-yl) carbonodithioate
Potassium O-tricyclo[5.2.1.0]dec-8-yl carbonodithioate
tricyclodecane-9-yl-xanthogenate
D-609 POTASSIUM
Carbonodithioic acid, O-(octahydro-4,7-methano-1H-inden-5-yl) ester, potassium salt
Tricyclodecan-9-yl xanthate
MFCD00171401
EINECS 280-379-9
D609 POTASSIUM SALT
Tricyclodecan-9-yl xanthogenate

Biological Activity

[Description]:

D609 is a selective competitive inhibitor of phosphatidyl choline-specific phospholipase C (PC-PLC), with Ki of 6.4 μM.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Cancer

[Target]

Ki: 6.4 μM (PC-PLC)

[References]

[1]. Kalluri HS, et al. D609 inhibits the proliferation of neural progenitor cells.Neuroreport. 2010 Jul 14;21(10):700-3.

[2]. Milhas D, et al. The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase-Dependent and -Independent Cell Death in T Lymphocytes.Int J Mol Sci. 2012;13(7):8834-52. Epub 2012 Jul 16.

[3]. Gusain A, et al. Anti-proliferative effects of tricyclodecan-9-yl-xanthogenate (D609) involve ceramide and cell cycle inhibition.Mol Neurobiol. 2012 Jun;45(3):455-64. Epub 2012 Mar 14.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.24 g/cm3

[ Boiling Point ]:
303.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₅KOS₂

[ Molecular Weight ]:
266.465

[ Flash Point ]:
137.5ºC

[ Exact Mass ]:
266.020142

[ PSA ]:
66.62000

[ LogP ]:
3.31010

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation.

Biochim. Biophys. Acta 1841(12) , 1672-82, (2015)

Most anti-cancer agents induce apoptosis, however, a development of multidrug resistance in cancer cells and defects in apoptosis contribute often to treatment failure. Here, the mechanism of curcumin...

Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice.

Infect. Immun. 83(2) , 780-91, (2015)

Mycobacterium abscessus is a pathogenic, rapidly growing mycobacterium involved in pulmonary and cutaneo-mucous infections worldwide, to which cystic fibrosis patients are exquisitely susceptible. The...

Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation.

Shock 44 , 157-65, (2015)

Multiorgan failure is a major cause of late mortality following trauma. Oxidative stress generated during shock/resuscitation contributes to tissue injury by priming the immune system for an exaggerat...