1-Monolinolein

Names

[ Name ]:
1-Monolinolein

[Synonym ]:
MFCD00056654
2,3-Dihydroxypropyl (9Z,12Z)-9,12-octadecadienoate
2,3-Dihydroxypropyl linoleate
1-Monolinolein
1-Monolinoleoyl-rac-glycerol
9,12-Octadecadienoic acid, 2,3-dihydroxypropyl ester, (9Z,12Z)-
1-Linoleoyl-rac-glycerol
1-([cis,cis]-9,12-octadecadienoyl)-rac-glycerol 1-Monolinolein
EINECS 218-901-4
UNII:MGG581HK1Y
2,3-Dihydroxypropyl (9Z,12Z)-octadeca-9,12-dienoate
1-Linoleoyl Glycerol

Biological Activity

[Description]:

1-Linoleoyl glycerol (1-LG) is a fatty acid glycerol that has been isolated from S. chinensis roots.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Cardiovascular Disease

[Target]

The (R)-1-Linoleoyl Glycerol and (S)-1-Linoleoyl Glycerol exhibit Lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitory activities with IC50 values of 45.0 and 52.0 μM, respectively[1].

[References]

[1]. Lee WS, et al. Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3573-5.

[Related Small Molecules]

U73122 | D609 | Darapladib | Quinacrine (dihydrochloride) | FIPI | Melittin | Varespladib | CAY10650 | AA26-9 | ML348 | Tanshinone I | Methyl Arachidonyl Fluorophosphonate | ML 349 | Lp-PLA2 -IN-1 | SPK-601

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
485.0±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₈O₄

[ Molecular Weight ]:
354.524

[ Flash Point ]:
157.0±20.8 °C

[ Exact Mass ]:
354.277008

[ PSA ]:
66.76000

[ LogP ]:
6.19

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.489

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ HS Code ]:
2916190090

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Controlling anisotropic drug diffusion in lipid-Fe3O4 nanoparticle hybrid mesophases by magnetic alignment.

Langmuir 29(4) , 999-1004, (2013)

We present a new strategy to control the anisotropic diffusion of hydrophilic drugs in lyotropic liquid crystals via the dispersion of magnetic nanoparticles in the mesophase, followed by reorientatio...

pH-responsive lyotropic liquid crystals for controlled drug delivery.

Langmuir 27 , 5296-5303, (2011)

We present a food-grade lyotropic liquid crystal system, capable of responding to pH variations with a reversible switch in both the structure and physical properties. The system, which is composed by...

Lyotropic liquid crystal systems in drug delivery.

Drug Discov. Today 15 , 1032-1040, (2010)

Lyotropic liquid crystal systems, such as reversed bicontinuous cubic and hexagonal mesophases, are attracting more and more attention because of their unique microstructures and physicochemical prope...

Related Compounds

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