B-Raf IN 6

Names

[ Name ]:
B-Raf IN 6

Biological Activity

[Description]:

B-Raf IN 6 (compound 2c) is a potent inhibitor of protein kinase B-Raf with an IC50 of 1.7 nM. B-Raf IN 6 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> Raf

[References]

[1]. Schneider M, et al. Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding. J Med Chem. 2022;65(2):1552-1566.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₁F₃N₆O₂S₂

[ Molecular Weight ]:
546.59

Related Compounds

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