B-Raf IN 7

Names

[ CAS No. ]:
2477725-07-6

[ Name ]:
B-Raf IN 7

Biological Activity

[Description]:

B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC50 of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC50 values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> Raf

[Target]

B-Raf:110.23 ± 0 nM (IC50)


[References]

[1]. Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H16N6O3

[ Molecular Weight ]:
328.33

Related Compounds