B-Raf IN 11

Names

[ Name ]:
B-Raf IN 11

[Synonym ]:
N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide

Biological Activity

[Description]:

B-Raf IN 11 (ZINC72115182) is a selective B-RafV600E inhibitor (IC50=76 nM), shows selectivity for B-RafV600E over B-RafWT with selectivity of 3.1-fold. B-Raf IN 11 can be used in colorectal cancer research[1]

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> Raf

[Target]

B-RafV600E:76 nM (IC50)

BRAFWT:238 nM (IC50)

[References]

[1]. Yao H, et al. Identification and Characterization of Small-Molecule Inhibitors to Selectively Target the DFG-in over the DFG-out Conformation of the B-Raf Kinase V600E Mutant in Colorectal Cancer. Arch Pharm (Weinheim). 2016 Oct;349(10):808-815.

Chemical & Physical Properties

[ Boiling Point ]:
634.2°C

[ Molecular Formula ]:
C₁₇H₁₄BrF₂N₃O₃S

[ Molecular Weight ]:
458.27700

[ Exact Mass ]:
456.99100

[ PSA ]:
100.30000

[ LogP ]:
5.14010

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%