B-Raf IN 9

Names

[ CAS No. ]:
2477725-18-9

[ Name ]:
B-Raf IN 9

Biological Activity

[Description]:

B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> Raf

[Target]

B-Raf:24.97 ± 0. nM (IC50)


[References]

[1]. Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H20N4OS

[ Molecular Weight ]:
400.50

Related Compounds