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B-Raf IN 1

Names

[ CAS No. ]:
950736-05-7

[ Name ]:
B-Raf IN 1

[Synonym ]:
N-[3-(3-{4-[(Dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
Benzamide, N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)-
B-Raf IN 1

Biological Activity

[Description]:

B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.

[Related Catalog]:

Research Areas >> Cancer

[Target]

B-Raf:24 nM (IC50)


[In Vitro]

B-Raf IN 1 (Compound 10n) inhibits WM 266-4 and HT29 cells with IC50s of 0.92 and 0.78 μM, respectively[1].

[References]

[1]. Berger DM, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.


[Related Small Molecules]

PLX8394 | Doramapimod (BIRB 796) | PLX-4720 | LGX 818 | LY 3009120 | GW5074 | RAF265 (CHIR-265) | AZ 628 | RAF709 | CEP-32496 | GDC-0879 | LXH254 | TAK-632 | PLX7904 | HG6-64-1

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C29H24F3N5O

[ Molecular Weight ]:
515.529

[ Exact Mass ]:
515.193298

[ PSA ]:
62.53000

[ LogP ]:
4.39

[ Appearance of Characters ]:
yellow solid

[ Index of Refraction ]:
1.621

[ Storage condition ]:
-20℃

Related Compounds