mGAT3/4-IN-1

Names

[ CAS No. ]:
2556833-57-7

[ Name ]:
mGAT3/4-IN-1

Biological Activity

[Description]:

mGAT3/4-IN-1 (compound 19b) is a potent mGAT3/mGAT4 inhibitor, with pIC50 values of 5.31 and 5.24, respectively. mGAT3/4-IN-1 exhibits a significant tactile allodynia reduction in diabetic neuropathic mice[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

pIC50: 4.86 ± 0.10 (mGAT1), 4.98 ± 0.05 (mGAT2), 5.31 ± 0.04 (mGAT3), 5.24 ± 0.05 (mGAT4)[1]


[References]

[1]. Zaręba P, et al. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem. 2020 Feb 15;188:111920.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H31ClN2O2S2

[ Molecular Weight ]:
503.12

Related Compounds