2556833-57-7

2556833-57-7 structure

Name: mGAT3/4-IN-1
Chemical Name: mGAT3/4-IN-1
CAS Number: 2556833-57-7
Molecular Formula: C₂₆H₃₁ClN₂O₂S₂
Molecular Weight: 503.12
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2022-07-02 09:25:57
Modify Date: 2024-01-14 14:23:48
mGAT3/4-IN-1 (compound 19b) is a potent mGAT3/mGAT4 inhibitor, with pIC50 values of 5.31 and 5.24, respectively. mGAT3/4-IN-1 exhibits a significant tactile allodynia reduction in diabetic neuropathic mice[1].

Name	mGAT3/4-IN-1

Description	mGAT3/4-IN-1 (compound 19b) is a potent mGAT3/mGAT4 inhibitor, with pIC50 values of 5.31 and 5.24, respectively. mGAT3/4-IN-1 exhibits a significant tactile allodynia reduction in diabetic neuropathic mice[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	pIC50: 4.86 ± 0.10 (mGAT1), 4.98 ± 0.05 (mGAT2), 5.31 ± 0.04 (mGAT3), 5.24 ± 0.05 (mGAT4)[1]
References	[1]. Zaręba P, et al. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem. 2020 Feb 15;188:111920.

Molecular Formula	C₂₆H₃₁ClN₂O₂S₂
Molecular Weight	503.12