nAChR agonist 2

Names

[ Name ]:
nAChR agonist 2

[Synonym ]:
(2S,4E)-N-Methyl-5-(3-pyridinyl)-4-penten-2-amine
4-Penten-2-amine, N-methyl-5-(3-pyridinyl)-, (2S,4E)-
nAChR agonist 2

Biological Activity

[Description]:

nAChR agonist 2 (compound 8) is a selective alpha4beta2 (α4β2) nAChR agonist (Kd=26 nM)[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[References]

[1]. Huang X, et al. Modeling subtype-selective agonists binding with alpha4beta2 and alpha7 nicotinic acetylcholine receptors: effects of local binding and long-range electrostatic interactions. J Med Chem. 2006;49(26):7661-7674.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
300.4±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₆N₂

[ Molecular Weight ]:
176.26

[ Flash Point ]:
135.5±25.9 °C

[ Exact Mass ]:
176.131348

[ LogP ]:
1.18

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.545

Related Compounds

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