PARP1-IN-9

Names

[ CAS No. ]:
2494000-71-2

[ Name ]:
PARP1-IN-9

Biological Activity

[Description]:

PARP1-IN-9 (Compound 5c) is a PARP1 inhibitor with an IC50 of 30.51 nM. PARP1-IN-9 induces cell apoptosis and shows anticancer activity. PARP1-IN-9 has higher potency than Olaparib (HY-10162) [1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> PARP
Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP1:30.51 nM (IC50)


[In Vitro]

PARP1-IN-9 (Compound 5c) shows antiproliferative activity with an IC50 of 3.65 μM against MDA-MB-436 cancer cell line[1].

[References]

[1]. Eldin A Osman E, et al. Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors. Bioorg Chem. 2020 Nov;104:104198.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H21N3O5

[ Molecular Weight ]:
359.38

Related Compounds