2494000-71-2

2494000-71-2 structure

2494000-71-2 structure

Name: PARP1-IN-9
Chemical Name: PARP1-IN-9
CAS Number: 2494000-71-2
Molecular Formula: C₁₈H₂₁N₃O₅
Molecular Weight: 359.38
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2022-09-01 20:44:59
Modify Date: 2024-01-16 07:40:28
PARP1-IN-9 (Compound 5c) is a PARP1 inhibitor with an IC50 of 30.51 nM. PARP1-IN-9 induces cell apoptosis and shows anticancer activity. PARP1-IN-9 has higher potency than Olaparib (HY-10162) [1].

Name	PARP1-IN-9

Description	PARP1-IN-9 (Compound 5c) is a PARP1 inhibitor with an IC50 of 30.51 nM. PARP1-IN-9 induces cell apoptosis and shows anticancer activity. PARP1-IN-9 has higher potency than Olaparib (HY-10162) [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PARP1:30.51 nM (IC50)
In Vitro	PARP1-IN-9 (Compound 5c) shows antiproliferative activity with an IC50 of 3.65 μM against MDA-MB-436 cancer cell line[1].
References	[1]. Eldin A Osman E, et al. Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors. Bioorg Chem. 2020 Nov;104:104198.

Molecular Formula	C₁₈H₂₁N₃O₅
Molecular Weight	359.38