PALGLY

Names

[ Name ]:
PALGLY

[Synonym ]:
N-Ethanoyl-Hexadecanamide
PALGLY
N-hexadecanoyl glycine
Palmitoylglycine
QV1MV15
N-palmitatoylglycyne
N-(1-Oxohexadecyl)glycine
N-Hexadecanoylglycine
Glycine, N-(1-oxohexadecyl)-
Hexadecanoylaminoacetic acid N-palmitoyl glycine
Hexadecanoylaminoacetic acid,N-palmitoyl glycine
2-(Hexadecanoylamino)acetic acid
N-palmitoyl glycine
N-Palmitoylglycine

Biological Activity

[Description]:

Palmitoylglycine, a novel endogenous lipid, acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Palmitoylglycine induces transient influx of calcium followed by nitric oxide production via calcium-sensitive nitric-oxide synthase enzymes. Palmitoylglycine potently inhibits heat-evoked firing of nociceptive neurons in rat dorsal horn[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Neurological Disease

[References]

[1]. Neta Rimmerman, et al. N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Mol Pharmacol. 2008 Jul;74(1):213-24.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
491.8±28.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₃₅NO₃

[ Molecular Weight ]:
313.48

[ Flash Point ]:
251.2±24.0 °C

[ Exact Mass ]:
313.261688

[ PSA ]:
66.40000

[ LogP ]:
6.03

[ Appearance of Characters ]:
white to off-white

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.468

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: >10mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

¹H-NMR and MS based metabolomics study of the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet.

PLoS ONE 10(3) , e0120950, (2015)

Curcumin, a principle bioactive component of Curcuma longa L, is well known for its anti-hyperlipidemia effect. However, no holistic metabolic information of curcumin on hyperlipidemia models has been...

GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination.

PLoS ONE 8 , e60314, (2013)

The G-protein coupled receptor 55 (GPR55) is activated by lysophosphatidylinositols and some cannabinoids. Recent studies found prominent roles for GPR55 in neuropathic/inflammatory pain, cancer and b...

Glycine N-acyltransferase-like 3 is responsible for long-chain N-acylglycine formation in N18TG2 cells.

J. Lipid Res. 57 , 781-90, (2016)

Long-chain fatty acid amides are signaling lipids found in mammals and other organisms; however, details of the metabolic pathways for the N-acylglycines and primary fatty acid amides (PFAMs) have rem...

Related Compounds

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