VRK-IN-1

Names

[ Name ]:
VRK-IN-1

Biological Activity

[Description]:

VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

IC50: 150 nM (VRK1)[1]

[In Vitro]

VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM[1]. VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM[1].

[References]

[1]. Serafim RAM, et, al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₁F₄NO₂

[ Molecular Weight ]:
349.28

Related Compounds

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