ANO1-IN-1

Names

[ Name ]:
ANO1-IN-1

Biological Activity

[Description]:

ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC50 of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel

[Target]

IC50: 2.56 μM (ANO1), 15.43 μM (ANO2)[1]

[In Vitro]

ANO1-IN-1 (Compound 9c) (10 μM) significantly suppresses migration and invasion of U251 cells[1]. ANO1-IN-1 and TMZ combination brings about remarkable synergistic effects in suppressing proliferation of GBM cells[1].

[References]

[1]. Choi SH, et al. Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers. Eur J Med Chem. 2020 Dec 15;208:112688.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₈N₂O₂S

[ Molecular Weight ]:
336.49

Related Compounds

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