Neuroinflammatory-IN-2

Names

[ CAS No. ]:
2361384-14-5

[ Name ]:
Neuroinflammatory-IN-2

Biological Activity

[Description]:

Neuroinflammatory-IN-2 (compound 7i) is a potent anti-neuroinflammatory agent with an IC50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H2O2-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease

[Target]

MAO-B:10.30 μM (IC50)


[In Vitro]

Neuroinflammatory-IN-2 (compound 7i) (1 and 10 μM) dramatically increases the viability of H2O2-treated PC-12 cells by 70.2% and 81.6% at 1 and 10 μM, respectively[1]. Neuroinflammatory-IN-2 (0.5, 2.5 and 10.0 μM) inhibits NO expression in LPS-stimulated BV-2 cells by 32.4%, 46.7% and 57.2% at the concentration of 0.5, 2.5 and 10.0 μM respectively; and inhibits TNF-α by 35.8%, 53.1% and 76.5%, respectively[1].

[References]

[1]. Yang Z, et al. Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease. Bioorg Med Chem. 2020 Apr 1;28(7):115374.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H27FN2O3

[ Molecular Weight ]:
422.49

Related Compounds