2,4-Thiazolidinedione

Names

[ Name ]:
2,4-Thiazolidinedione

[Synonym ]:
EINECS 218-941-2
2(5H)-Thiazolone, 4-hydroxy-
2,4-Thiazolidindione
usafek-5496
2,4-dioxothiazolidine
Thiazolidinedione
2,4-Thiazolidinedione
1,3-Thiazolidine-2,4-dione
2-thiazolidin-4-one
2,4-thiazolidinone
thiazolidine-2,4-dione
2,4-Thiazolinedione
4-Hydroxy-1,3-thiazol-2(5H)-one
MFCD00005478
TZD

Biological Activity

[Description]:

2,4-Thiazolidinedione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

PPARγ 激动剂。胰岛素增敏剂。

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
178-179 ºC (19 mmHg)

[ Melting Point ]:
123-126 ºC

[ Molecular Formula ]:
C₃H₃NO₂S

[ Molecular Weight ]:
117.13

[ Flash Point ]:
138.7±19.3 °C

[ Exact Mass ]:
116.988449

[ PSA ]:
71.47000

[ LogP ]:
-0.54

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.577

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ5775000

CHEMICAL NAME :: 2,4-Thiazolidinedione

CAS REGISTRY NUMBER :: 2295-31-0

BEILSTEIN REFERENCE NO. :: 0110700

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C3-H3-N-O2-S

MOLECULAR WEIGHT :: 117.13

WISWESSER LINE NOTATION :: T5SVMV EHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 335 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 9,274,1954

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
XJ5775000

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Cytotoxicity of thiazolidinedione-, oxazolidinedione- and pyrrolidinedione-ring containing compounds in HepG2 cells.

Toxicol. In Vitro 29 , 1887-96, (2015)

Liver damage occurred in some patients who took troglitazone (TGZ) for type II diabetes. The 2,4-thiazolidinedione (TZD) ring in TGZ's structure has been implicated in its hepatotoxicity. To further e...

Differential cardiovascular outcomes after dipeptidyl peptidase-4 inhibitor, sulfonylurea, and pioglitazone therapy, all in combination with metformin, for type 2 diabetes: a population-based cohort study.

PLoS ONE 10 , e0124287, (2015)

Data on the comparative effectiveness of oral antidiabetics on cardiovascular outcomes in a clinical practice setting are limited. This study sought to determine whether a differential risk of cardiov...

Effects of Various 5,7-Dihydroxyflavone Analogs on Adipogenesis in 3T3-L1 Cells.

Biol. Pharm. Bull. 38 , 1794-800, (2015)

We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the a...