Podocarpusflavone A

Names

[ Name ]:
Podocarpusflavone A

[Synonym ]:
8-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
Podocarpusflavone A
4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-
9-Methylacridin
4-Methylakridin
4'''-methylamentoflavone
4-Methylacridin
1-Methylacridin
ACRIDINE,4-METHYL
4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-
4-methyl-acridine

Biological Activity

[Description]:

Podocarpusflavone A is a DNA topoisomerase I inhibitor, have moderated anti-proliferative activity induce cell apoptosis in MCF-7, is developing anti-tumor drugstarget: DNA topoisomerase IIn vitro: podocarpusflavone-A show significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 4.56-16.24 μg/mL) and induce cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. PF (40 ug/mL, 24 hr) significantly induced about 10 folds of cell deaths and growth arrest in S-phase than the control group.

[Related Catalog]:

Research Areas >> Cancer

Natural Products >> Flavonoids

[Target]

Topoisomerase I:119.425 μM (IC50)

[References]

[1]. Pen-Ho Yeh et al. Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaiiJ Tradit Complement Med. 2012 Jul;2(3):220-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
879.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₁H₂₀O₁₀

[ Molecular Weight ]:
552.484

[ Flash Point ]:
295.2±27.8 °C

[ Exact Mass ]:
552.105652

[ PSA ]:
170.80000

[ LogP ]:
4.15

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.750

[ Storage condition ]:
2-8℃

Related Compounds

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