NG 52

Names

[ Name ]:
NG 52

[Synonym ]:
Ethanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-
2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine NG-52
OLP
2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
compound 52
2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol
3bpr
2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)ethanol
NG-52
NG 52

Biological Activity

[Description]:

NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).IC50 value: 7 uM [1]Target: Cdc28pCompound 52 inhibited growth in a drug-sensitized yeast strainwith a GI 50 of 30 uM. In contrast, the closely related compound 52Me proved to be a significantly weaker inhibitor of yeast growth (GI50=200 uM).

[Related Catalog]:

Research Areas >> Cancer

[Target]

cdc2-cyclin B:0.34 μM (IC50)

Pho85p:2 nM (IC50)

[References]

[1]. ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
587.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₉ClN₆O

[ Molecular Weight ]:
346.815

[ Flash Point ]:
309.2±32.9 °C

[ Exact Mass ]:
346.130890

[ PSA ]:
91.12000

[ LogP ]:
1.54

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.688

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Related Compounds

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