PARP1-IN-14

Names

[ CAS No. ]:
2098639-70-2

[ Name ]:
PARP1-IN-14

Biological Activity

[Description]:

PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1−/−) and Capan-1 (BRCA2−/−) cells with IC50 values below 0.3 nM[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP1:0.6 ± 0.1 nM (IC50)

[References]

[1]. Wang P, et al. Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities. Eur J Med Chem. 2023 Nov 5;259:115709.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₄FN₇O₃

[ Molecular Weight ]:
525.53

Related Compounds

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