2098639-70-2

2098639-70-2 structure

Name: PARP1-IN-14
Chemical Name: PARP1-IN-14
CAS Number: 2098639-70-2
Molecular Formula: C₂₈H₂₄FN₇O₃
Molecular Weight: 525.53
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2024-04-06 16:33:03
Modify Date: 2024-04-06 16:33:03
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1−/−) and Capan-1 (BRCA2−/−) cells with IC50 values below 0.3 nM[1].

Name	PARP1-IN-14

Description	PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1−/−) and Capan-1 (BRCA2−/−) cells with IC50 values below 0.3 nM[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PARP1:0.6 ± 0.1 nM (IC50)
References	[1]. Wang P, et al. Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities. Eur J Med Chem. 2023 Nov 5;259:115709.

Molecular Formula	C₂₈H₂₄FN₇O₃
Molecular Weight	525.53