H10

Names

[ CAS No. ]:
2084811-68-5

[ Name ]:
H10

Biological Activity

[Description]:

PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> Epigenetics >> PARP

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP14:490 nM (IC50)

PARP1

[References]

[1]. Peng B, et al. Small Molecule Microarray Based Discovery of PARP14 Inhibitors. Angew Chem Int Ed Engl. 2017 Jan 2;56(1):248-253.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₇N₇O₇S

[ Molecular Weight ]:
557.58

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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