Isobavachalcone

Names

[ CAS No. ]:
20784-50-3

[ Name ]:
Isobavachalcone

[Synonym ]:
(2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
4-Hydroxyisocordoim
2',4',4-trihydroxy-3'-prenylchalcone
4-Hydroxyisocordoin
Isobacachalcone
4,2',4'-trihydroxy-3'-prenylchalcone
(E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-
Corylifolinin

Biological Activity

[Description]:

Isobavachalcone(Corylifolinin) is a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.IC50 value:Target: Isobavachalcone inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Isobavachalcone exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Isobavachalcone hows antifungal activity.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Cancer

Natural Products >> Flavonoids

[References]

[1]. Jing Hui; Zhou Xinglu; Dong Xiaowu; Cao Ji; Zhu Hong; Lou Jianshu; Hu Yongzhou; He Qiaojun; Yang Bo Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells.Cancer letters (2010), 294(2):167-177

[2]. Nishimura R et al. Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma. Biol Pharm Bull. 2007 Oct;30(10):1878-83.

[3]. Zhao S, et al. Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells.Int J Mol Med. 2012 Jul 16.

[4]. Kuete V, Sandjo LP.Isobavachalcone: an overview.Chin J Integr Med. 2012 Jul;18(7):543-7. Epub 2012 Jul 7.

[5]. Zhang Y, Chen Z.Separation of isomeric bavachin and isobavachalcone in the fructus Psoraleae by capillary electrophoresis-mass spectrometry.J Sep Sci. 2012 Jul;35(13):1644-50.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
549.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₀O₄

[ Molecular Weight ]:
324.370

[ Flash Point ]:
299.9±26.6 °C

[ Exact Mass ]:
324.136169

[ PSA ]:
77.76000

[ LogP ]:
5.21

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.658

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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