Tubulysin A
Names
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C43H65N5O10S
[ Molecular Weight ]:
844.06900
[ Exact Mass ]:
843.44500
[ PSA ]:
239.99000
[ LogP ]:
7.06310
[ Appearance of Characters ]:
colorless or white
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
organic solvents: soluble
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H311-H315-H319-H331-H335
[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T
[ Risk Phrases ]:
23/24/25-36/37/38
[ Safety Phrases ]:
36/37-45
[ RIDADR ]:
UN 2811 6.1 / PGIII
Articles
Mol. Biol. Cell 26 , 2769-87, (2015)
Assembly and sealing of the tight junction barrier are critically dependent on the perijunctional actin cytoskeleton, yet little is known about physical and functional links between barrier-forming pr...
Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.Biochem. J. 396 , 235-242, (2006)
Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and an...
An antibody to de-N-acetyl sialic acid containing-polysialic acid identifies an intracellular antigen and induces apoptosis in human cancer cell lines.PLoS ONE 6 , e27249, (2011)
Polysialic acid (PSA), an α2,8-linked homopolymer of N-acetylneuraminic acid (Neu5Ac), is developmentally regulated and its expression is thought to be restricted to a few tissues in adults. Recently,...