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Eribulin mesylate

Names

[ CAS No. ]:
441045-17-6

[ Name ]:
Eribulin mesylate

[Synonym ]:
UNII-AV9U0660CW
E7389
Halaven
(1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,35R,36S)-20-[(2S)-3-Amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-bis(methylene)-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1.1.1.1.0.0.0]hentetracontan-24-one methanesulfonate (1:1)
Eribulin mesylate

Biological Activity

[Description]:

Eribulin mesylate is a microtubule targeting agent that is used in the treatment of metastatic breast cancer. It inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Research Areas >> Cancer

[References]

[1]. Okouneva, T., et al., Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase. Mol Cancer Ther, 2008. 7(7): p. 2003-11.

[2]. Smith, J.A., et al., Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. Biochemistry, 2010. 49(6): p. 1331-7.

[3]. Towle, M.J., et al., Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res, 2011. 71(2): p. 496-505.


[Related Small Molecules]

Nocodazole | Monomethyl auristatin E | VcMMAE | Mertansine | Epothilone D | Vinorelbine (ditartrate) | epothilone B | McMMAF | MMAF (Hydrochloride) | Ixabepilone | Taltobulin | Estramustine phosphate sodium | Ansamitocin P-3 | Combretastatin A4 disodium phosphate | Cevipabulin

Chemical & Physical Properties

[ Molecular Formula ]:
C41H63NO14S

[ Molecular Weight ]:
826.002

[ Exact Mass ]:
825.396912

[ PSA ]:
209.14000

[ LogP ]:
4.72310

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds