(+)-Corynoline

Names

[ Name ]:
(+)-Corynoline

[Synonym ]:
(11S,13R,14R)-corynoline
13-Methylchelidonine
13-methyl-chelidonine
Corynoline
[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-, (5bR,6S,12bR)-

Biological Activity

[Description]:

Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9.

[2]. Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
504.2±50.0 °C at 760 mmHg

[ Melting Point ]:
217-218ºC

[ Molecular Formula ]:
C₂₁H₂₁NO₅

[ Molecular Weight ]:
367.395

[ Flash Point ]:
258.7±30.1 °C

[ Exact Mass ]:
367.141968

[ PSA ]:
60.39000

[ LogP ]:
3.23

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.659

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H330

[ Precautionary Statements ]:
P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ RIDADR ]:
UN 1544PSN1 6.1 / PGII

Precursor & DownStream

Precursor

DownStream

Related Compounds

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