Acetylcorynoline

Names

[ Name ]:
Acetylcorynoline

[Synonym ]:
(5bR)-6t-acetoxy-5b,13-dimethyl-(5br,12bc)-5b,6,7,12b,13,14-hexahydro-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine
[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-, acetate (ester), (5bR,6S,12bR)-
corynoline acetate
(+)-O-acetyl-corynoline
N1513
Acetylcorynoline
(+)-Corynolin-acetat
O-Acetyl-13-methylchelidonine
O-acetyl-13-methyl-chelidonine
(+)-Corynolin-O-acetat

Biological Activity

[Description]:

Acetylcorynoline is the major alkaloid component derived from Corydalis bungeana, and has anti-inflammatory properties[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Acetylcorynoline significantly inhibits the secretion of tumor necrosis factor-α, interleukin-6, and interleukin-12p70 by LPS-stimulated Dendritic cells (DCs)[1]. Acetylcorynoline significantly inhibits LPS-induced activation of IκB kinase and mitogen-activated protein kinase[1].

[References]

[1]. Fu RH, et al. Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease. Neuropharmacology. 2014 Jul;82:108-20.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
499.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₃NO₆

[ Molecular Weight ]:
409.432

[ Flash Point ]:
255.7±28.7 °C

[ Exact Mass ]:
409.152527

[ PSA ]:
66.46000

[ LogP ]:
4.05

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.667

[ Storage condition ]:
2-8C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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