<Suppliers Price>

Dual AChE-MAO B-IN-2

Names

[ CAS No. ]:
1801157-64-1

[ Name ]:
Dual AChE-MAO B-IN-2

Biological Activity

[Description]:

Dual AChE-MAO B-IN-2 is a potent AChE and MAO B dual inhibitor with IC50s of 0.12 µM and 0.01 µM for b>AChE and MAO B, respectively. Dual AChE-MAO B-IN-2 has the potential for the research of Alzheimer’s disease[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

MAO-B:4.5 μM (Ki)


[In Vitro]

Dual AChE-MAO B-IN-2 (compound 1) shows a +5.5 °C increase in the MAO B enzyme Tm value[1].

[References]

[1]. Ekström F, et al. Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures. ACS Med Chem Lett. 2022, 13(3):499-506.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H25NO4

[ Molecular Weight ]:
415.48

Related Compounds