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13-Hydroxyisobakuchiol

Names

[ CAS No. ]:
178765-49-6

[ Name ]:
13-Hydroxyisobakuchiol

[Synonym ]:
4-[(1E,3S,5E)-7-Hydroxy-3,7-dimethyl-3-vinyl-1,5-octadien-1-yl]phenol
Phenol, 4-[(1E,3S,5E)-3-ethenyl-7-hydroxy-3,7-dimethyl-1,5-octadien-1-yl]-

Biological Activity

[Description]:

Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease, depression, and cocaine addiction[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter

[Target]

IC50: 0.58 μM (dopamine transporter) IC50: 0.69 μM (norepinephrine transporter)[1]


[References]

[1]. Gang Zhao, et al. Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions. Biochem Pharmacol. 2008 May 1;75(9):1835-47.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
429.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H24O2

[ Molecular Weight ]:
272.382

[ Flash Point ]:
195.8±23.3 °C

[ Exact Mass ]:
272.177643

[ LogP ]:
3.85

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.574

Related Compounds