chloropyrimidine
Names
[ CAS No. ]:
1722-12-9
[ Name ]:
chloropyrimidine
[Synonym ]:
2-Chloro-4-deoxyuracil
2-Chloro-pyrimindine
EINECS 217-020-2
chloro-pyrimidine
2-Chloropyrimindine
MFCD00006060
chloropyrimidine
2-pyrimidyl chloride
2-Chloropyrimidine
2-Cl-pyrimidine
Pyrimidine, 2-chloro-
2CPY X HCL
2-Chloro
pyrimidin-2-yl chloride
2-chloro-pyrimidine
2-chloro-pyrimidin
2-choropyrimidine
PYRIMIDINE,2-CHLORO
2-pyrimidinyl chloride
2-chloropyrimide
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
199.2±0.0 °C at 760 mmHg
[ Melting Point ]:
63-66 °C(lit.)
[ Molecular Formula ]:
C4H3ClN2
[ Molecular Weight ]:
114.533
[ Flash Point ]:
109.2±4.3 °C
[ Exact Mass ]:
113.998474
[ PSA ]:
25.78000
[ LogP ]:
0.36
[ Vapour Pressure ]:
0.5±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.535
[ Storage condition ]:
Refrigerator
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H319
[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/38
[ Safety Phrases ]:
S26-S37/39
[ RIDADR ]:
2811
[ WGK Germany ]:
3
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2933599090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933599090
[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Org. Chem. 74(8) , 3221-4, (2009)
A cobalt-catalyzed cross-coupling of aryl halides with 2-chloropyrimidines or 2-chloropyrazines is reported in satisfactory to high yields. The key step of this procedure is the formation of aromatic ...
Ru-catalysed C-H arylation of indoles and pyrroles with boronic acids: scope and mechanistic studies.Chemistry 21(14) , 5380-6, (2015)
The Ru-catalysed C2-H arylation of indoles and pyrroles by using boronic acids under oxidative conditions is reported. This reaction can be applied to tryptophan derivatives and tolerates a wide range...
Expedient parallel synthesis of 2-amino-4-heteroarylpyrimidines.Org. Lett. 7(19) , 4113-6, (2005)
[reaction: see text] An expedient synthesis of diverse 2-amino-4-heteroarylpyrimidines via a 2-chloropyrimidine intermediate is described. A series of potentially biologically active analogues have be...