2,4-Dichloropyrimidine

Names

[ Name ]:
2,4-Dichloropyrimidine

[Synonym ]:
4-DichloropyriMidine
2,4-dichloro-pyrimidine
MFCD00006061
Pyrimidine, 2,4-dichloro-
2,4-Dichlorpyrimidin
2,4-Dichloropyrimidi
2,4-Dichloropyrimidine
2,6-dichloropyrimidine
dichloropyrimidine
EINECS 223-508-6
2,4-DICHLORO PYRIMIDINE

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
209.1±0.0 °C at 760 mmHg

[ Melting Point ]:
57-61 °C(lit.)

[ Molecular Formula ]:
C₄H₂Cl₂N₂

[ Molecular Weight ]:
148.978

[ Flash Point ]:
104.3±5.4 °C

[ Exact Mass ]:
147.959503

[ PSA ]:
25.78000

[ LogP ]:
1.15

[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.559

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S28A

[ RIDADR ]:
1759

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.

J. Med. Chem. 50 , 3497, (2007)

The vanilloid receptor-1 (VR1 or TRPV1) is a member of the transient receptor potential (TRP) family of ion channels and plays a role as an integrator of multiple pain-producing stimuli. From a high-t...

One-pot Double Suzuki Couplings of Dichloropyrimidines.

Synthesis 2010(16) , 2721-2724, (2010)

An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed, which enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solve...

An efficient route to 4-aryl-5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine.

Org. Lett. 8(2) , 269-72, (2006)

[reaction: see text] Starting from 2,4-dichloropyrimidine, a concise synthetic route to medicinally important 4-aryl-5-pyrimidinylimidazoles is described. Sequential substitution of the 4- and 2-chlor...