2-methylthio-4-chloropyrimidine

Names

[ Name ]:
2-methylthio-4-chloropyrimidine

[Synonym ]:
2-methylthio-4-chloropyrimidine
4-Chloro-2-(methylthio)pyrimidine
4-Chloro-2-methylthiopyrimidine
MFCD00006083
4-Chloro-2-(methylsulfanyl)pyrimidine
Pyrimidine, 4-chloro-2-(methylthio)-
4-chloro-2-methylsulfanylpyrimidine
EINECS 256-500-6

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
243.1±13.0 °C at 760 mmHg

[ Melting Point ]:
−2 °C(lit.)

[ Molecular Formula ]:
C₅H₅ClN₂S

[ Molecular Weight ]:
160.625

[ Flash Point ]:
100.8±19.8 °C

[ Exact Mass ]:
159.986191

[ PSA ]:
51.08000

[ LogP ]:
1.81

[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.595

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 1760 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Concise total syntheses of variolin B and deoxyvariolin B.

J. Org. Chem. 70(16) , 6204-12, (2005)

The total synthesis of the marine alkaloid variolin B has been achieved in 8 steps and 17% overall yield, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involve...

Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.

J. Med. Chem. 50 , 1146, (2007)

By the screening of a combinatorial library for inhibitors of nitric oxide (NO) formation by the inducible isoform of nitric oxide synthase (iNOS) using a whole-cell assay, 2-(imidazol-1-yl)pyrimidine...

Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.

J. Med. Chem. 50 , 3497, (2007)

The vanilloid receptor-1 (VR1 or TRPV1) is a member of the transient receptor potential (TRP) family of ion channels and plays a role as an integrator of multiple pain-producing stimuli. From a high-t...