5-Bromo-2,4-dichloropyrimidine

Names

[ Name ]:
5-Bromo-2,4-dichloropyrimidine

[Synonym ]:
5-bromo-2,4-dichloropyrimdine
Pyrimidine, 5-bromo-2,4-dichloro-
5-Brom-2,4-dichlor-pyrimidin
5-Bromo-2,4-dichloropyrimidine
MFCD00127818
2,4,4-TRIMETHYLCYCLOPENTANONE
5-Bromo-2,4-dichloro-pyrimidine
2,4-Dichloro-5-bromo pyrimidine
5-Bromo-2,4-dichloror-pyrimidine

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
287.5±20.0 °C at 760 mmHg

[ Melting Point ]:
29-30 °C(lit.)

[ Molecular Formula ]:
C₄HBrCl₂N₂

[ Molecular Weight ]:
227.874

[ Flash Point ]:
127.7±21.8 °C

[ Exact Mass ]:
225.870010

[ PSA ]:
25.78000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.605

[ Storage condition ]:
Keep Cold

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H314-H317

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P2 (EN 143) respirator cartridges;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R23/24/25;R34

[ Safety Phrases ]:
S26-S27-S36/37/39-S45

[ RIDADR ]:
UN 3263 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors.

J. Med. Chem. 56(23) , 9683-92, (2013)

Abnormal activation or overexpression of Mer receptor tyrosine kinase has been implicated in survival signaling and chemoresistance in many human cancers. Consequently, Mer is a promising novel cancer...

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Bioorg. Med. Chem. Lett. 17(22) , 6206-11, (2007)

The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented.

Synthesis , 861, (2006)