5-Bromouracil

Names

[ CAS No. ]:
51-20-7

[ Name ]:
5-Bromouracil

[Synonym ]:
Uracil,5-bromo
2,4(1H,3H)-Pyrimidinedione, 5-bromo-
Bromouracil
5-Bromo-2,4(1H,3H)-pyrimidinedione
5-bromo-uraci
5-bromopyrimidine-2,4-diol
5-bromo-2,4-dioxopyrimidine
5-Bromouracil
5-BrUra
5-Br-uracil
BROMOURACIL,5
5-bromo-uracil
EINECS 200-084-0
MFCD00006017
5-bromopyrimidine-2,4(1H,3H)-dione

Biological Activity

[Description]:

5-Bromouracil is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

5-溴尿嘧啶通过诱导 A 型样 DNA 破坏核小体定位。

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
384ºC

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C₄H₃BrN₂O₂

[ Molecular Weight ]:
190.98

[ Exact Mass ]:
189.937775

[ PSA ]:
65.72000

[ LogP ]:
-0.35

[ Index of Refraction ]:
1.590

[ Water Solubility ]:
SOLUBLE IN COLD WATER

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ9060000

CHEMICAL NAME :: Uracil, 5-bromo-

CAS REGISTRY NUMBER :: 51-20-7

LAST UPDATED :: 199709

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C4-H3-Br-N2-O2

MOLECULAR WEIGHT :: 191.00

WISWESSER LINE NOTATION :: T6MVMVJ EE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5 gm/kg/2W-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 400 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :: Insect - grasshopper

DOSE/DURATION :: 10 mg

REFERENCE :: IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921- Volume(issue)/page/year: 38,305,1963

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R46

[ Safety Phrases ]:
S36/37-S53-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YQ9060000

[ HS Code ]:
29335995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.

Nat. Commun. 6 , 6715, (2015)

The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery...

Bench scale synthesis of p-hydroxybenzoic acid using whole-cell nitrilase of Gordonia terrae mutant E9.

Bioprocess Biosyst. Eng. 38 , 1267-79, (2015)

Mutants of Gordonia terrae were generated using chemical mutagens for better activity, stability and higher substrate/product tolerance of its nitrilase enzyme. Mutant E9 showed two-time increase in a...