2-Aminopyrimidine
Names
[ CAS No. ]:
109-12-6
[ Name ]:
2-Aminopyrimidine
[Synonym ]:
2-pyrimidineamine
Pyrimidone imide
2-Pyrimidinemine
2-amino-pyrimidin
2-Aminopyrimidine
2-Pyrimidinamine
pyrimidin-2-amine
2-AMINO PYRIMIDINE
MFCD00006089
2-pyridiylamine
2-Pyrimidylamine
EINECS 203-648-4
2-AP
Pyrimidin-2-amin
2-amino-1,3-diazabenzene
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
148.0±23.0 °C at 760 mmHg
[ Melting Point ]:
122-126 °C(lit.)
[ Molecular Formula ]:
C4H5N3
[ Molecular Weight ]:
95.10
[ Flash Point ]:
43.3±22.6 °C
[ Exact Mass ]:
95.048347
[ PSA ]:
51.80000
[ LogP ]:
-0.89
[ Vapour Pressure ]:
4.3±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.632
[ Storage condition ]:
-20°C
[ Water Solubility ]:
SOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UV6326000
- CHEMICAL NAME :
- Pyrimidine, 2-amino-
- CAS REGISTRY NUMBER :
- 109-12-6
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C4-H5-N3
- MOLECULAR WEIGHT :
- 95.12
- WISWESSER LINE NOTATION :
- T6N CNJ BZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 790 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Microorganism - not otherwise specified
- DOSE/DURATION :
- 50 mg/L
- REFERENCE :
- SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 6,1623,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5674 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 14 No. of Employees: 1216 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36-S37/39
[ RIDADR ]:
UN 2811
[ WGK Germany ]:
3
[ RTECS ]:
UV6326000
[ HS Code ]:
2933599090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933599090
[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Acta Crystallogr. B 68(Pt 4) , 431-43, (2012)
The antifungal drug 5-fluorocytosine (4-amino-5-fluoro-1,2-dihydropyrimidin-2-one) was cocrystallized with five complementary compounds in order to better understand its drug-receptor interaction. The...
Synthesis and Structural Study of Some Pyrimidinium Hexafluoridosilicates.Acta Chim. Slov. 62 , 297-303, (2015)
The synthesis and spectroscopic characterization of some pyrimidinium hexafluoridosilicate salts with the formula (RH)2[SiF]6 (where R = 2-aminopyrimidine (1), cytosine (2) and 5-cyanocytosine (3)) is...
Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives.Eur. J. Med. Chem. 45 , 379-86, (2010)
A series of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidines derivatives were synthesized using a convenient synthetic route. We evaluate the isosteric replacement of methy...