2-Aminopyrimidine

Names

[ CAS No. ]:
109-12-6

[ Name ]:
2-Aminopyrimidine

[Synonym ]:
2-pyrimidineamine
Pyrimidone imide
2-Pyrimidinemine
2-amino-pyrimidin
2-Aminopyrimidine
2-Pyrimidinamine
pyrimidin-2-amine
2-AMINO PYRIMIDINE
MFCD00006089
2-pyridiylamine
2-Pyrimidylamine
EINECS 203-648-4
2-AP
Pyrimidin-2-amin
2-amino-1,3-diazabenzene

Biological Activity

[Description]:

2-Aminopyrimidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
148.0±23.0 °C at 760 mmHg

[ Melting Point ]:
122-126 °C(lit.)

[ Molecular Formula ]:
C₄H₅N₃

[ Molecular Weight ]:
95.10

[ Flash Point ]:
43.3±22.6 °C

[ Exact Mass ]:
95.048347

[ PSA ]:
51.80000

[ LogP ]:
-0.89

[ Vapour Pressure ]:
4.3±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.632

[ Storage condition ]:
-20°C

[ Water Solubility ]:
SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV6326000

CHEMICAL NAME :: Pyrimidine, 2-amino-

CAS REGISTRY NUMBER :: 109-12-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H5-N3

MOLECULAR WEIGHT :: 95.12

WISWESSER LINE NOTATION :: T6N CNJ BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 50 mg/L

REFERENCE :: SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 6,1623,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5674 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 14 No. of Employees: 1216 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ RTECS ]:
UV6326000

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Cocrystals of 5-fluorocytosine. I. Coformers with fixed hydrogen-bonding sites.

Acta Crystallogr. B 68(Pt 4) , 431-43, (2012)

The antifungal drug 5-fluorocytosine (4-amino-5-fluoro-1,2-dihydropyrimidin-2-one) was cocrystallized with five complementary compounds in order to better understand its drug-receptor interaction. The...

Synthesis and Structural Study of Some Pyrimidinium Hexafluoridosilicates.

Acta Chim. Slov. 62 , 297-303, (2015)

The synthesis and spectroscopic characterization of some pyrimidinium hexafluoridosilicate salts with the formula (RH)2[SiF]6 (where R = 2-aminopyrimidine (1), cytosine (2) and 5-cyanocytosine (3)) is...

Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives.

Eur. J. Med. Chem. 45 , 379-86, (2010)

A series of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidines derivatives were synthesized using a convenient synthetic route. We evaluate the isosteric replacement of methy...