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Donitriptan

Names

[ CAS No. ]:
170912-52-4

[ Name ]:
Donitriptan

[Synonym ]:
Donitriptan

Biological Activity

[Description]:

Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT1B Receptor:9.4 (pKi)

5-HT1D Receptor:9.3 (pKi)


[References]

[1]. Muñoz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91.

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Boiling Point ]:
727.1ºC at 760mmHg

[ Molecular Formula ]:
C23H25N5O2

[ Molecular Weight ]:
403.47700

[ Flash Point ]:
393.6ºC

[ Exact Mass ]:
403.20100

[ PSA ]:
98.38000

[ LogP ]:
2.97158

[ Vapour Pressure ]:
5.34E-21mmHg at 25°C

[ Index of Refraction ]:
1.688

Related Compounds