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BIM 23056

Names

[ CAS No. ]:
150155-61-6

[ Name ]:
BIM 23056

[Synonym ]:
D-2-Phenylglycine
Donitriptan hydrochloride
D-Phe-ol hydrochloride
D-Phe-Phe-Tyr-D-Trp-Lys-Val-Phe-D-Nal-NH2
D-PHENYLGLYCINE
H-D-PHG-OH

Biological Activity

[Description]:

BIM 23056, a linear octapeptide, is a potent sst3 and sst5 somatostatin receptor antagonist with Ki values of 10.8, 5.7, respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor
Research Areas >> Neurological Disease

[In Vitro]

BIM 23056 has Ki values of 142, 16.6, >1000 for sst1, sst4, sst2 , respectively[1].

[References]

[1]. Y C Patel, et al. Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology. 1994 Dec;135(6):2814-7.

[2]. W Feniuk, et al. Further evidence from functional studies for somatostatin receptor heterogeneity in guinea-pig isolated ileum, vas deferens and right atrium. Br J Pharmacol. 1995 Jul;115(6):975-80.

Chemical & Physical Properties

[ Molecular Formula ]:
C71H81N11O9

[ Molecular Weight ]:
1232.47000

[ Exact Mass ]:
1231.62000

[ PSA ]:
334.85000

[ LogP ]:
9.61110

Related Compounds