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PNU 96415E

Names

[ CAS No. ]:
170856-41-4

[ Name ]:
PNU 96415E

Biological Activity

[Description]:

PNU-96415E is a selective D4/5-HT2A antagonist. PNU-96415E may have potential antipsychotic efficacy[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

D4 Receptor

5-HT2A Receptor


[In Vivo]

PNU-96415E blockes 5-HTP-induced bead twitches in mice and stereotypic behaviours produced by high doses of amphetamine and methylphenidate[1].

[References]

[1]. Kulkarni SK, et al. Dopamine D4 receptors and development of newer antipsychotic drugs. Fundam Clin Pharmacol. 2000;14(6):529-539.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H27Cl2FN2O

[ Molecular Weight ]:
413.35600

[ Exact Mass ]:
412.14800

[ PSA ]:
15.71000

[ LogP ]:
5.25870


Related Compounds

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