(S)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride

Names

[ Name ]:
(S)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride

[Synonym ]:
MFCD32182633

Biological Activity

[Description]:

(S)-PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₈Cl₂N₂O

[ Molecular Weight ]:
301.21

[ Storage condition ]:
Inert atmosphere,2-8°C