PNU 109291
Names
Biological Activity
[Description]:
PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1].
[Related Catalog]:
[In Vivo]
PNU109291 (0.24、2.4、7.3、24.4、73.3 nmol/kg;皮下注射) 减少猪的三叉神经节刺激引起的硬脑膜血浆外渗[1]。 PNU109291 (3 µM) 抑制大鼠弗氏佐剂 (CFA) 诱发的 EPSC(兴奋性突触后电流),但不抑制注射盐水的处理组[2]。 Animal Model: 200-500g, male Hartley guinea pigs[1] Dosage: 0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg Administration: S.c.; 60 min before electrical stimulation Result: Dose-dependently decreased plasma protein extravasation with an IC50 value of 4.2 nmol/kg.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C24H31N3O3
[ Molecular Weight ]:
409.52
[ Exact Mass ]:
409.23700
[ PSA ]:
54.04000
[ LogP ]:
3.27470