187665-60-7

187665-60-7 structure

Name: PNU 109291
Chemical Name: (1R)-1-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamide
CAS Number: 187665-60-7
Molecular Formula: C₂₄H₃₁N₃O₃
Molecular Weight: 409.52
Create Date: 2016-06-23 23:55:03
Modify Date: 2024-01-03 21:49:58
PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1].

Name	(1R)-1-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamide
Synonyms	DMNPE-caged ATP diammonium salt

Description	PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vivo	PNU109291 (0.24、2.4、7.3、24.4、73.3 nmol/kg；皮下注射) 减少猪的三叉神经节刺激引起的硬脑膜血浆外渗[1]。 PNU109291 (3 µM) 抑制大鼠弗氏佐剂 (CFA) 诱发的 EPSC（兴奋性突触后电流），但不抑制注射盐水的处理组[2]。 Animal Model: 200-500g, male Hartley guinea pigs[1] Dosage: 0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg Administration: S.c.; 60 min before electrical stimulation Result: Dose-dependently decreased plasma protein extravasation with an IC50 value of 4.2 nmol/kg.
References	[1]. Cutrer FM, et al. Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis. Neuropharmacology. 1999 Jul;38(7):1043-53. [2]. Winters BL, et al. Inflammation induces developmentally regulated sumatriptan inhibition of spinal synaptic transmission. Br J Pharmacol. 2020 Aug;177(16):3730-3743.