PNU 109291
Modify Date: 2025-09-10 11:18:50
PNU 109291 structure
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Common Name | PNU 109291 | ||
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| CAS Number | 187665-60-7 | Molecular Weight | 409.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H31N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PNU 109291PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1]. |
| Name | (1R)-1-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamide |
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| Synonym | More Synonyms |
| Description | PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1]. |
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| Related Catalog | |
| In Vivo | PNU109291 (0.24、2.4、7.3、24.4、73.3 nmol/kg；皮下注射) 减少猪的三叉神经节刺激引起的硬脑膜血浆外渗[1]。 PNU109291 (3 µM) 抑制大鼠弗氏佐剂 (CFA) 诱发的 EPSC（兴奋性突触后电流），但不抑制注射盐水的处理组[2]。 Animal Model: 200-500g, male Hartley guinea pigs[1] Dosage: 0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg Administration: S.c.; 60 min before electrical stimulation Result: Dose-dependently decreased plasma protein extravasation with an IC50 value of 4.2 nmol/kg. |
| References |
| Molecular Formula | C24H31N3O3 |
|---|---|
| Molecular Weight | 409.52 |
| Exact Mass | 409.23700 |
| PSA | 54.04000 |
| LogP | 3.27470 |
| DMNPE-caged ATP diammonium salt |