Zicronapine

Names

[ Name ]:
Zicronapine

[Synonym ]:
UNII-QZV11V7G6A
Zicronapine

Biological Activity

[Description]:

Zicronapine is an antipsychotic medication with a strong pro-cognitive effect in animal models and the potential to treat a number of neurological and psychiatric diseases. Zicronapine has potent antagonistic effects at dopamine D1/D2, and serotonin 5-HT2A receptors.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Lopez De Diego, Heidi. et al. Succinate and malonate salts of trans-4-(1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and their preparation, pharmaceutical compositions, and use as medicaments, particularly as antipsychotics. WO2005016900A1

[2]. Lundbeck H. A/S. The clinical phase III programme commenced on zicronapine. 20 Jan 2011.

[3]. Lundbeck H, A/S. Zicronapine shows significant positive data in clinical phase II in the treatment of patients with schizophrenia –planning for continued clinical work. Press release No. 392 18 December 2009.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₇ClN₂

[ Molecular Weight ]:
354.91600

[ Exact Mass ]:
354.18600

[ PSA ]:
6.48000

[ LogP ]:
4.81850

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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