170381-16-5

170381-16-5 structure

Name: Zicronapine
Chemical Name: 4-[(1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl]-1,2,2-trimethylpiperazine
CAS Number: 170381-16-5
Molecular Formula: C₂₂H₂₇ClN₂
Molecular Weight: 354.91600
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2016-04-15 02:23:10
Modify Date: 2024-01-09 17:19:56
Zicronapine is an antipsychotic medication with a strong pro-cognitive effect in animal models and the potential to treat a number of neurological and psychiatric diseases. Zicronapine has potent antagonistic effects at dopamine D1/D2, and serotonin 5-HT2A receptors.

Name	4-[(1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl]-1,2,2-trimethylpiperazine
Synonyms	UNII-QZV11V7G6A Zicronapine

Description	Zicronapine is an antipsychotic medication with a strong pro-cognitive effect in animal models and the potential to treat a number of neurological and psychiatric diseases. Zicronapine has potent antagonistic effects at dopamine D1/D2, and serotonin 5-HT2A receptors.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Lopez De Diego, Heidi. et al. Succinate and malonate salts of trans-4-(1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and their preparation, pharmaceutical compositions, and use as medicaments, particularly as antipsychotics. WO2005016900A1 [2]. Lundbeck H. A/S. The clinical phase III programme commenced on zicronapine. 20 Jan 2011. [3]. Lundbeck H, A/S. Zicronapine shows significant positive data in clinical phase II in the treatment of patients with schizophrenia –planning for continued clinical work. Press release No. 392 18 December 2009.

846052-64-0

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846061-48-1

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Literature: H. LUNDBECK A/S Patent: WO2006/86984 A1, 2006 ; Location in patent: Page/Page column 24 ;

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64-18-6

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Detail

Literature: H. LUNDBECK A/S Patent: WO2005/16900 A1, 2005 ; Location in patent: Page/Page column 28-29; 31-32 ; WO 2005/016900 A1

170381-17-6

170381-16-5

Literature: H. LUNDBECK A/S Patent: WO2005/16900 A1, 2005 ; Location in patent: Page/Page column 29 ; WO 2005/016900 A1

153627-83-9

170381-16-5

84477-72-5

170381-16-5

Precursor 4
846052-64-0 50-00-0 64-18-6 84477-72-5
DownStream 0